Background: Tissue engineering principles can be exploited to enhance alveolar and peri-implant\r\nbone reconstruction by applying such biological factors as platelet-derived growth factors. The\r\nobjective of the present study is to investigate the effect of autologous plasma-rich in growth\r\nfactors (on the healing of peri-implant bone in canine mandible).\r\nMaterials and Methods: In this prospective experimental animal study, two healthy canines of\r\nthe Iranian mix breed were selected. Three months after removing their premolar teeth on both\r\nsides of the mandible, 12 implants of the Osteo Implant Corporationsystem, 5 mm in diameter\r\nand 10 mm in length, were selected to be implanted. Plasma rich in growth factors (PRGF) were\r\napplied on six implants while the other six were used as plain implants without the plasma. The\r\nimplants were installed in osteotomy sites on both sides of the mandible to be removed after 4\r\nweeks with the surrounding bones using a trephine bur. Mesio-distal sections and implant blocks,\r\n50 �µ in diameter containing the peri-implant bone, were prepared By basic fuchin toluidine-bluefor\r\nhistological and histomorphometric evaluation by optical microscope. The data were analyzed using\r\nMann-Whitney Test (P<0.05).\r\nResults: The bone trabeculae and the type of bone generation in PRGF and control groups had\r\nno statistically significant differences (P=0.261, P=0.2) although the parameters showed higher\r\nmeasured values in the PRGF group. However, compared to the control, application of PRGF had\r\nsignificantly increased bone-to-implant contact (P=0.028)\r\nConclusion: Based on the results, it may be concluded that application of PRGF on the surface\r\nof implant may enhance bone-to-implant contact.
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